This paper examined the attitude of Nigeria science students towards Schooling. The study was an ex-post facto type of research. Four hypotheses were tested at the 0.05 level of significance. The sample was made of 200 Juniour and Senior Secondary school science students (110 males, and 90 females with mean age of 14.5years, Standard Deviation=1.83) purposely selected from five co-educational secondary schools in Ogun State, Nigeria. A 20-item questionnaire developed by this researcher and titled, Students’ Attitude Towards Schooling Questionnaire (STATSQ) was used for data collection (? = 0.72). The data was analyzed using simple descriptive statistics (percentages, frequency counts, mean and standard deviation) and t-test. Findings revealed that the general attitude of the science students towards schooling was positive. In addition, it revealed; a significant gender difference in the attitudes of male and female students in favour of females; no significant difference in the attitudes towards schooling of students from public and private schools; a significant difference between the attitude of science students in lower and upper secondary levels in favour of the lower level students; no significant difference in the attitudes of science students from urban and rural areas; and, no significant difference in the attitude towards schooling of muslim and Christian science students.