This study presents a longitudinal analysis of the progressive implementation of research-based learning (RBL) in a senior-level biochemistry course at the University of the Basque Country (UPV/EHU) over a ten-year period. The course initially followed a traditional format consisting of disconnected lectures and laboratory sessions. Throughout the decade, the methodology evolved into a fully integrated RBL framework, where students assume an active role in their learning.

In the current model, lecture-based instruction has shifted towards student-driven learning, in which learners are responsible for acquiring foundational concepts and collaboratively designing the methodology for laboratory experiments. These practical sessions are no longer isolated activities but are instead structured around a single, shared research problem that is explored through diverse experimental approaches. This integrated project culminates in the writing of a research article. Students receive formative feedback from instructors on a first draft, which they revise before submitting the final version for summative evaluation.

Data collected through institutional and custom-designed surveys revealed a consistent increase in student satisfaction, engagement, and self-perceived learning outcomes. The study highlights the development of critical scientific competencies such as experimental design, analytical thinking, and scientific communication. Moreover, it underscores the value of iterative feedback and student autonomy in fostering a deeper connection with the discipline.

These findings contribute to the growing body of evidence supporting RBL as a high-impact practice in science education. The success of this evolving approach demonstrates how rethinking course design can bridge theoretical instruction with practical application, promote ownership of learning, and cultivate meaningful mentorship between students and faculty.

Keywords: Research-based learning, student autonomy, biochemistry education, active learning, laboratory integration.